Precision Glutamine

Fuel for Your Gut Lining

5g/day | AM on empty stomach, or dissolved in water | Paired with: Precision Gut™ (Stack 7)

Why This Matters

Your gut lining replaces itself every 3–5 days. That’s one of the fastest turnover rates of any tissue in your body. And the primary fuel your intestinal cells need to do that job? Glutamine.

Glutamine is the most abundant amino acid in your bloodstream, and your enterocytes — the cells that form the barrier between what’s inside your gut and what enters your bloodstream — are the single biggest consumers of it. When glutamine availability is adequate, those cells can maintain tight junctions, repair damage, and keep the barrier intact. When it’s depleted (which happens under stress, illness, intense exercise, or chronic inflammation), the barrier weakens. And when the barrier weakens, you get what’s often called “leaky gut” — technically, increased intestinal permeability — which allows endotoxins and inflammatory molecules to cross into circulation.

Here’s the data point that matters: in a randomised controlled trial, enteral glutamine supplementation reduced plasma zonulin by 40% and significantly decreased circulating endotoxin. Zonulin is the molecule that opens tight junctions — so reducing it is a direct measure of improved barrier integrity.

Precision Glutamine™ is specifically designed as the powder companion for Precision Gut™. While the capsule stack provides the probiotic diversity and the fibre feeds the beneficial bacteria from above, glutamine works from the cellular side — giving the lining itself the fuel it needs to stay intact and functional.

Product Details

Detail Specification Active Ingredient L-Glutamine (pharmaceutical grade) Source CanPrev — Canadian-manufactured Daily Dose 5g (one level scoop) Timing AM on empty stomach for best absorption, or in water any time Format Unflavoured powder Primary Pairing Precision Gut™ (Stack 7)

The Evidence — Why We Chose This

Every product in the Precision line is here for a reason. Here’s the science behind this one.

Gut Barrier Repair

RCT: enteral glutamine reduced plasma zonulin by 40% and significantly decreased circulating endotoxin. Zonulin is the biomarker for intestinal permeability — so this is a direct, measurable improvement in gut barrier function. Effective at doses of 5g/day and above.

Enterocyte Fuel

Glutamine is the primary metabolic fuel for enterocytes and colonocytes. It provides the nitrogen and carbon backbone needed for rapid cell turnover in the intestinal epithelium — the tissue with one of the highest proliferation rates in the body.

Synergy with Probiotics and Fibre

Glutamine acts synergistically with the probiotic and prebiotic components in Precision Gut™ — the probiotics improve microbial diversity from the luminal side, the fibre feeds butyrate-producing bacteria, and glutamine repairs the cellular barrier from the inside. It’s a three-layer approach.

Stress and Exercise Recovery

Glutamine demand increases significantly during physiological stress, illness, and intense exercise — conditions where gut barrier compromise is most likely. Supplementation during these periods helps prevent the permeability increase that often follows.

Important Considerations

This product is well-researched and appropriate for most healthy adults. The following points are worth knowing — particularly if you are taking prescription medications or have specific health conditions. When in doubt, share this information with your prescribing physician.

Liver Conditions

Glutamine is metabolised in the liver. If you have severe liver disease (cirrhosis, hepatic encephalopathy), please discuss with your healthcare provider before supplementing, as glutamine may contribute to ammonia load in compromised liver function.

Cancer History

Some cancer cells preferentially use glutamine as a fuel source. If you have an active malignancy or are undergoing cancer treatment, please consult your oncologist before adding glutamine supplementation.

These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. The evidence summaries provided are for educational purposes and represent published research findings. If you are pregnant, nursing, taking medication, or have a health condition, please consult your healthcare provider before use.

Complete Your Protocol

Precision Glutamine™ is designed to pair with Precision Gut™ and Precision Fibre™ for a complete gut restoration protocol.

Not sure where to start? Book a complimentary 15-minute coaching call.