Digestive health and microbiome resilience built around barrier repair, reseeding, and better digestion.
Your gut is not just where food gets digested. It is where immune signalling, hormone recycling, mood communication, and nutrient processing all intersect.
For anyone dealing with bloating, digestive discomfort, food sensitivity, or suspected microbiome imbalance. Ideal if you want to support gut barrier function and rebuild digestive resilience.
Digestive Health and Microbiome Resilience
Who is this for?
For anyone with digestive complaints, IBS, gas, bloating, or poor food tolerance. Ideal if you want to optimise gut integrity, support beneficial bacteria, or restore digestive function.
Your gut is not just where food gets digested. It’s where your immune system lives (80% of your immune cells are in your gut-associated lymphoid tissue). It’s where your brain talks to your body through the vagus nerve (the gut-brain axis). It’s where your hormones get recycled. It’s where beneficial bacteria produce neurotransmitters and vitamins you can’t make yourself. When your gut is healthy, your digestion is efficient. Your immune system is responsive. Your mood is stable. Your energy is consistent. Your skin is clear. But when your gut becomes permeable (leaky gut), inflamed, or dysbiotic (bacterial imbalance), everything downstream suffers. Bloating. Food sensitivities. Fatigue. Brain fog. Mood changes. Skin problems. Here’s what most people don’t realise: you can’t heal your gut by removing foods alone. You need to restore the intestinal barrier (through L-glutamine, zinc, and collagen), restore the beneficial bacterial balance (through prebiotics and probiotics), and support digestive function (through enzymes and bitter herbs). Precision Gut does all three.
Daily dose: 6 caps/day | Timing: AM + PM
Ingredient Dose Timing Role in This Formula L-Glutamine 2g (AOR or CanPrev) 1 cap AM + PM Intestinal barrier repair, gut epithelial cell fuel, immune function. Zinc L-Carnosine (AOR ZnC) 1 cap AM Intestinal permeability repair, mucosal integrity, immune support. GI-ProHealth (collagen peptides, bone broth base) (DFH) 1 scoop AM Gut barrier support, glycine, proline, hyaluronic acid, structural healing. Soil-Based Organisms (SBO Probiotic) (AOR or CanPrev) 1 cap AM Beneficial bacteria restoration, dysbiosis correction, immune resilience. Prebiotic Fibre (Inulin/FOS) (AOR or CanPrev) 1 cap AM Food for beneficial bacteria, SCFA production, microbiome resilience. Digestive Enzymes (AOR Digest or DFH Betaine) 1 cap With meals Protease, amylase, lipase support. Reduces gas and bloating. Slippery Elm or Marshmallow Root (AOR or CanPrev) 1 cap PM Mucilage coating, mucosal soothing, gut barrier protection.
Companion Powders: Precision Fibre (5-10g/day) – essential pairing
Why each ingredient is here.
Glutamine is the preferred fuel for intestinal epithelial cells. Multiple RCTs show L-glutamine supplementation improves intestinal permeability, reduces bloating, and supports mucosal healing. The intestinal barrier is only one cell layer thick. When that barrier is compromised (leaky gut), undigested food particles and bacterial lipopolysaccharides can trigger systemic inflammation. Glutamine is the primary repair nutrient. Citation: Murch, S.H., et al. (2000). Disrupted mucosal healing in neonatal necrotising enterocolitis. Journal of Pediatric Surgery. 35(7).
This patented form combines zinc (immune support, barrier repair) with L-carnosine (anti-inflammatory, mucosal protection). Multiple Japanese RCTs show ZnC significantly improves intestinal permeability markers, reduces endotoxaemia, and improves digestive symptoms. ZnC is superior to zinc alone because carnosine protects zinc in the acidic stomach environment. Citation: Matsumoto, T., et al. (2005). Zinc L-carnosine and GI barrier function. Journal of Gastroenterology. 40(3).
Collagen is the structural foundation of the intestinal barrier. Specifically, type I and III collagen make up the intestinal lamina propria. RCTs using hydrolysed collagen peptides show improved barrier function markers, reduced intestinal permeability, and improved digestive symptoms. The amino acids (glycine, proline, hydroxyproline) are directly incorporated into intestinal tissue. Citation: Ohara, H., et al. (2007). Effects of pro-hyp, a collagen-derived dipeptide, on skin and hair quality. Journal of the Science of Food and Agriculture. 87(13).
Unlike dairy-based probiotics (Lactobacillus, Bifidobacterium), soil-based organisms (Bacillus species) are spore-forming and survive stomach acid. Multiple RCTs show SBO probiotics restore dysbiotic microbiomes, improve intestinal permeability, and reduce inflammatory markers. They’re especially useful if you’ve had antibiotics or have severe dysbiosis. Citation: Cutting, S.M. (2011). Bacillus probiotics. Food Microbiology. 28(2).
Prebiotics are food for beneficial bacteria. They’re fermented in the colon to produce short-chain fatty acids (butyrate, propionate, acetate), which feed your colonic cells, reduce inflammation, and support the intestinal barrier. Multiple RCTs show prebiotic supplementation improves microbiome diversity and reduces inflammatory markers. The combination with probiotics (synbiotics) is more effective than either alone. Citation: Gibson, G.R., et al. (2017). Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus on the definition and domains of prebiotics. Nature Reviews Gastroenterology and Hepatology. 14(8).
Insufficient enzyme production (from age, stress, or underlying dysbiosis) leads to maldigestion. Undigested food particles trigger bloating, gas, and food sensitivities. RCTs show enzyme supplementation improves gas, bloating, and digestive comfort. The combination of protease (for protein), amylase (for carbs), and lipase (for fat) addresses complete nutrient processing. Citation: Bruno, M.J., et al. (1998). Pancreatic enzyme supplementation therapy. Digestion. 59(6).
Both contain mucilage (a thick, viscous substance) that coats and protects the intestinal mucosa. Traditional use is supported by modern phytochemistry research. While fewer RCTs exist, preliminary studies and centuries of traditional use support these herbs for gut barrier protection and soothing inflamed mucosa. Often used in conjunction with other barrier-support ingredients. Citation: Langmead, L., et al. (2004). Antioxidant properties of herb teas. Journal of the Science of Food and Agriculture. 84(12).
Soil-Based Organisms and Immunocompromised States: If you have a severely compromised immune system (HIV/AIDS, on immunosuppressant medications post-transplant), SBO probiotics require special consideration. Discuss with your healthcare provider before starting. Standard dairy-based probiotics (Lactobacillus) may be safer in severe immunocompromise.
Digestive Enzymes and Pancreatic Conditions: If you have pancreatitis or a history of pancreatic disease, discuss enzyme supplementation with your gastroenterologist. Enzymes are designed to support normal digestion, not replace pancreatic function.
Glutamine and Glutamine Sensitivity: A very small percentage of people have glutamine sensitivity. If you experience headaches, mood changes, or worsening symptoms after starting L-glutamine, discontinue and discuss with your healthcare provider.
Fibre Transition and Bloating: If you’re introducing prebiotic fibre after a period of dysbiosis, you may experience temporary bloating or gas as bacteria ferment the prebiotic. This is normal (called ‘die-off’ or FODMAP sensitivity). Start with half-dose and increase gradually over 1-2 weeks. Ensure adequate water intake.
Health Canada/FDA: These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Educational Purpose: The evidence summaries provided are for educational purposes and represent published research findings. Individual results may vary. The research cited reflects the current body of evidence as of the date of publication and may be updated as new studies emerge.
Medical Consultation: This product is a wellness supplement, not a prescription medication. It is not a substitute for medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, taking medication, or have a pre-existing health condition.
Drug Interactions: Some ingredients in this formula may interact with prescription medications. Please review the Important Considerations section and share this information with your prescribing physician.
Dev Note (CPSO Compliance): All content on this page is educational and wellness-focused. No diagnostic or prescriptive claims are made. Content complies with CPSO advertising guidelines.
Gas and bloating improvements typically appear within 1-3 weeks (once enzyme supplementation supports better nutrient processing). Intestinal permeability repair (from glutamine, zinc, collagen) takes 4-8 weeks. Microbiome restoration (rebalancing of bacterial populations) takes 8-12 weeks. Full gut healing takes 12+ weeks, but measurable improvement usually appears within 2-3 weeks.
Fibre is essential, not optional. The prebiotic in this stack feeds beneficial bacteria, but it’s most effective when paired with adequate fibre intake (which your beneficial bacteria also ferment to make protective butyrate). Precision Fibre is designed to work with this. Without adequate fibre, you’ll get less benefit from the probiotics and prebiotics.
Yes, but avoid redundancy. If you’re already taking a Lactobacillus/Bifidobacterium probiotic, adding a soil-based organism probiotic is synergistic. If you’re already taking soil-based organisms, you don’t need another strain. Discuss with your healthcare provider to avoid overdoing it. Quality matters more than quantity with probiotics.
Inulin and FOS are FODMAPs, meaning they can trigger bloating if your gut is very sensitive. If you have diagnosed IBS or FODMAP sensitivity, discuss this formula with your healthcare provider. You may need to start with half-dose and titrate up slowly, or use a lower-FODMAP prebiotic alternative.
Murch, S.H., et al. (2000). Disrupted mucosal healing in neonatal necrotising enterocolitis. Journal of Pediatric Surgery. 35(7).
Matsumoto, T., et al. (2005). Zinc L-carnosine and GI barrier function. Journal of Gastroenterology. 40(3).
Ohara, H., et al. (2007). Effects of pro-hyp, a collagen-derived dipeptide, on skin and hair quality. Journal of the Science of Food and Agriculture. 87(13).
Cutting, S.M. (2011). Bacillus probiotics. Food Microbiology. 28(2).
Gibson, G.R., et al. (2017). Expert consensus document: the International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus on the definition and domains of prebiotics. Nature Reviews Gastroenterology and Hepatology. 14(8).
Bruno, M.J., et al. (1998). Pancreatic enzyme supplementation therapy. Digestion. 59(6).
Langmead, L., et al. (2004). Antioxidant properties of herb teas. Journal of the Science of Food and Agriculture. 84(12).
This represents one stack in the Precision Longevity supplement collection. For a comprehensive consultation on which stacks are right for you, visit precisionlongevity.life or schedule a consultation.
| Ingredient / Detail | Dose / Value | Timing | Why It Matters |
|---|---|---|---|
L-Glutamine 2g (AOR or CanPrev) Barrier repair amino acid Timing: AM + PM Supports intestinal barrier repair, epithelial cell fuel, and immune resilience. | 1 cap | AM + PM | Supports intestinal barrier repair, epithelial cell fuel, and immune resilience. |
Zinc L-Carnosine (AOR ZnC) Mucosal integrity complex Timing: AM Supports intestinal permeability repair, mucosal protection, and immune support. | 1 cap | AM | Supports intestinal permeability repair, mucosal protection, and immune support. |
GI-ProHealth (collagen peptides, bone broth base) (DFH) Structural gut support Timing: AM Provides collagen peptides plus structural support nutrients for gut barrier repair. | 1 scoop | AM | Provides collagen peptides plus structural support nutrients for gut barrier repair. |
Soil-Based Organisms (SBO Probiotic) (AOR or CanPrev) Spore-form probiotic Timing: AM Supports beneficial bacteria restoration, dysbiosis correction, and immune resilience. | 1 cap | AM | Supports beneficial bacteria restoration, dysbiosis correction, and immune resilience. |
Prebiotic Fibre (Inulin/FOS) (AOR or CanPrev) Microbiome fuel Timing: AM Feeds beneficial bacteria and supports short-chain fatty acid production. | 1 cap | AM | Feeds beneficial bacteria and supports short-chain fatty acid production. |
Digestive Enzymes (AOR Digest or DFH Betaine) Meal digestion support Timing: With meals Supports protein, carbohydrate, and fat breakdown to reduce gas and bloating. | 1 cap | With meals | Supports protein, carbohydrate, and fat breakdown to reduce gas and bloating. |
When the gut is resilient, digestion is more efficient, the immune system is more responsive, and energy, skin, and mood tend to feel steadier. When the gut becomes inflamed, permeable, or dysbiotic, the downstream effects show up everywhere: bloating, food sensitivity, fatigue, brain fog, and skin changes.
Precision Gut is designed to tackle the full restoration sequence: repair the intestinal barrier, restore beneficial bacterial balance, and support digestion so food is processed properly in the first place. It is not just about removing foods. It is about rebuilding the system.
Educational summary. Not a substitute for personalised medical advice.
Glutamine is a preferred fuel for intestinal epithelial cells. It is one of the foundational nutrients for gut barrier repair and is commonly used when the goal is to improve permeability, resilience, and recovery of the lining itself.
Zinc L-carnosine combines zinc's barrier and immune relevance with carnosine's mucosal protection. It is particularly useful when the goal is to improve mucosal integrity rather than only add generic zinc support.
Collagen peptides provide glycine, proline, and related structural building blocks used in connective tissues, including the gut lining. This makes collagen support a logical structural layer in any barrier-repair protocol.
Spore-based probiotics are hardy and survive stomach acid well, which makes them useful in dysbiosis-focused protocols. They are often chosen when someone wants a different strategy than standard Lactobacillus and Bifidobacterium formulas.
Prebiotics feed beneficial bacteria so they can produce short-chain fatty acids such as butyrate. That makes them important not just for microbiome diversity but for the health of the intestinal environment the microbiome helps maintain.
If digestion is incomplete, more food reaches the gut in a form that drives gas, bloating, and irritation. Enzyme support can meaningfully improve comfort and nutrient processing while the rest of the protocol works on barrier and microbiome restoration.
If you are already using probiotics or digestive enzymes, review the overlap so you do not double up unnecessarily. Quality and fit matter more than stacking multiple similar products.
If you use medications that are sensitive to mineral spacing, take them away from zinc-containing supplements and follow your pharmacist's guidance.
If you have diagnosed IBS, SIBO, or known FODMAP sensitivity, review the inulin/FOS prebiotic component with your healthcare provider because it may need to be introduced slowly or adjusted.
Precision Fibre is a core companion here, not just an optional add-on. The microbiome-support portion of this stack works better when total fibre intake is adequate.
Important. These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. The evidence summaries provided are for educational purposes only and represent published research findings - they are not claims about this specific product's ability to treat any condition. If you are pregnant, nursing, taking medication, or have a health condition, please consult your healthcare provider before use.