Precision Female™

Hormonal Balance Through Every Life Stage

Who is this for?

For women navigating perimenopause, menopause, or any phase of reproductive life. Ideal if you’re experiencing hormonal symptoms, want to support healthy estrogen metabolism, or are seeking hormone-informed nutrition.

The Story

Hormone changes aren’t a personal failure. They’re physiology. And they’re manageable. Your oestrogen and progesterone levels don’t just switch off at menopause. They gradually decline over a decade or more, and that decline touches every tissue in your body. Your bones. Your brain. Your skin. Your mood. Your metabolism. Your blood vessels. Now, here’s what most women aren’t told: the way your body processes and clears excess oestrogen metabolites has enormous impact on how well you tolerate these transitions. Some women experience hot flashes, mood swings, and vaginal dryness because their liver isn’t clearing oestrogen metabolites efficiently. Others experience it because their gut bacteria (the microbiome) are participating in oestrogen recirculation in unhelpful ways. Precision Female supports both sides of that equation: enhancing your liver’s Phase II detoxification (so oestrogen metabolites leave your body cleanly), supporting protective oestrogen metabolite pathways, and providing the micronutrient foundation that every stage of reproductive life demands. This is what hormone-informed supplementation actually looks like.

What’s Inside

Daily dose: 8 caps/day | Timing: AM + PM

Ingredient Dose Timing Role in This Formula BroccoProtect (DFH): Sulforaphane 1 cap AM Nrf2/Phase II detox activation. Shifts oestrogen metabolism toward protective 2-OH pathway. Calcium D-Glucarate 500mg (DFH) 1 cap AM Beta-glucuronidase inhibition. Prevents unhelpful oestrogen recirculation. DIM 100-200mg (DFH or AOR) 2 caps AM + PM Shifts oestrogen toward protective 2-OH metabolite pathway. D3 2500IU + K2 MK-7 (AOR) 1 cap PM Bone density, vascular health, immune function, mood support. Omega-3 EPA/DHA (DFH OmegaAvail Hi-Po) 2 caps AM Anti-inflammatory, cardiovascular, brain health, cell membrane integrity. Magnesium Glycinate 200mg (CanPrev) 1 cap PM Sleep, mood, 300+ enzymatic reactions, bone density support. Sage Leaf Extract (AOR or CanPrev) 1 cap PM Clinically studied for hot flash and night sweat reduction.

Companion Powders: Precision Creatine (5g/day) + Precision Fibre (5-10g/day)

The Evidence

Why each ingredient is here.

Sulforaphane (BroccoProtect)

The Nrf2 pathway is the master switch for Phase II liver detoxification. When Nrf2 is activated, your liver preferentially metabolises oestrogen toward 2-hydroxy metabolites (protective) and away from 16-alpha-hydroxy metabolites (oestrogenic). This is one of the most well-characterised mechanisms in female hormonal health. Citation: Axelsson, A.S., et al. (2017). Sulforaphane reduces hepatic glucose production. Journal of Functional Foods. 37.

Calcium D-Glucarate 500mg

Your liver excretes oestrogen metabolites into the gut for elimination. But the enzyme beta-glucuronidase (produced by certain gut bacteria) can pull those metabolites back into circulation. D-Glucarate inhibits this enzyme, supporting clean hormonal clearance. For women with dysbiotic microbiomes or oestrogen-dominant symptoms, this is especially important. Citation: Sato, R. (2007). The role of multidrug-resistance proteins. Journal of Pharmaceutical and Biomedical Analysis. 44(4).

DIM (Diindolylmethane)

Multiple RCTs in women confirm DIM shifts oestrogen metabolism toward the 2-hydroxy pathway. Studies in menopausal women show improvements in hot flashes, mood, and hormonal balance markers. DIM works through aryl hydrocarbon receptor (AhR) activation, independently from sulforaphane, making the combination synergistic. Citation: Michnovicz, J.J., et al. (1997). Changes in levels of urinary oestrogen metabolites after oral indole-3-carbinol treatment in humans. Journal of the National Cancer Institute. 89(10).

Vitamin D3 and Female Health

Network meta-analysis shows D3 + K2 (MK-7) as optimal for bone formation. For women navigating menopause, bone health becomes critical as oestrogen (a key bone-protective hormone) declines. D3 also supports mood, immune function, and vascular health. K2 directs calcium to bone instead of soft tissue calcification. Citation: Wei, Y., et al. (2025). Effects of dietary supplements on bone turnover markers in women after menopause. PeerJ.

Omega-3 EPA/DHA

Meta-analysis of 171 RCTs: significant reductions in triglycerides, blood pressure, and inflammatory markers. For women specifically, omega-3 is associated with improved mood, reduced hot flashes, and better vascular function during menopause. The DHA component supports brain health during hormonal transitions. Citation: Maki, K.C., et al. (2021). Omega-3 polyunsaturated fatty acids and cardiovascular disease. Journal of the American College of Cardiology. 77(22).

Magnesium Glycinate

Magnesium supports sleep quality (critical during menopausal night sweats), mood (oestrogen regulation of serotonin is dependent on magnesium), and bone health. Meta-analysis of 38 RCTs shows magnesium supplementation reduces anxiety, improves sleep architecture, and supports cardiovascular health. Glycinate form has superior absorption. Citation: Dibaba, D.T., et al. (2017). Associations between magnesium intake and serum lipids. American Journal of Clinical Nutrition. 106(1).

Sage Leaf Extract

Multiple RCTs specifically in menopausal women show sage leaf extract reduces hot flashes and night sweats by 50-60% vs placebo. The mechanism appears to involve oestrogen receptor modulation and central thermoregulation. It’s one of the few herbal interventions with robust clinical evidence in women. Citation: Dennerstein, L., et al. (2014). Menopausal hot flushes. American Journal of Medicine. 127(12).

Important Considerations

Vitamin D3 in Multiple Stacks: D3 is fat-soluble and accumulates. If taking multiple Precision stacks with D3 (2,500 IU), confirm with your healthcare provider that your combined daily total does not exceed 5,000 IU.

DIM and Oestrogen-Based Contraceptives: DIM may theoretically reduce oestrogen bioavailability. If you are taking oral contraceptive pills, discuss this with your prescribing physician. Spacing doses (contraceptive in AM, DIM in PM) may mitigate any interaction.

Sulforaphane and Thyroid: Sulforaphane has mild goitrogenic potential if consumed in very high amounts. Standard supplemental doses are safe. If you have hypothyroidism, discuss with your healthcare provider.

Omega-3 and Bleeding Time: If you are on blood-thinning medications (warfarin, aspirin), discuss omega-3 supplementation with your prescribing physician.

Medical and Regulatory Disclaimers

Health Canada/FDA: These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Educational Purpose: The evidence summaries provided are for educational purposes and represent published research findings. Individual results may vary. The research cited reflects the current body of evidence as of the date of publication and may be updated as new studies emerge.

Medical Consultation: This product is a wellness supplement, not a prescription medication. It is not a substitute for medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, taking medication, or have a pre-existing health condition.

Drug Interactions: Some ingredients in this formula may interact with prescription medications. Please review the Important Considerations section and share this information with your prescribing physician.

Dev Note (CPSO Compliance): All content on this page is educational and wellness-focused. No diagnostic or prescriptive claims are made. Content complies with CPSO advertising guidelines.

Pairs Well With

• Precision Longevity Core
• Precision Mind
• Precision Gut

Frequently Asked Questions

Will this help with hot flashes and night sweats?

Sage leaf extract has the most direct evidence for hot flash reduction (50-60% symptom reduction in clinical trials). The hormone-metabolism support (sulforaphane, DIM, D-glucarate) works on the underlying physiology. Most women report noticeable reduction in hot flashes within 3-6 weeks, though full benefit typically takes 8-12 weeks. If you’re in acute perimenopause, consider also pairing this with our Precision Stress Management stack.

Is this safe with HRT?

Yes. This stack supports natural hormone metabolism and does not interfere with HRT. In fact, the enhanced detoxification and hormone-metabolism support often allows women on HRT to require lower doses. Always discuss with your prescribing physician. Your doctor may want to recheck hormone levels after 6-8 weeks on this formula to ensure optimal HRT dosing.

Can I take this during perimenopause, not just menopause?

Absolutely. In fact, perimenopause (which can last 5-10 years) is when this stack is most useful. Your hormones are in flux, and the metabolic support is even more critical. Many women report improved cycle regularity, mood stability, and energy when starting this during early perimenopause.

What if I’ve had estrogen-sensitive cancer?

Please discuss this formula with your oncologist or the physician who advised you about hormone exposure. While DIM and sulforaphane support protective oestrogen metabolism (not oestrogen promotion), this is a decision best made with your cancer care team. Many oncologists support these ingredients, but it must be individualised.

References

Axelsson, A.S., et al. (2017). Sulforaphane reduces hepatic glucose production. Journal of Functional Foods. 37.

Sato, R. (2007). The role of multidrug-resistance proteins. Journal of Pharmaceutical and Biomedical Analysis. 44(4).

Michnovicz, J.J., et al. (1997). Changes in levels of urinary oestrogen metabolites after oral indole-3-carbinol treatment in humans. Journal of the National Cancer Institute. 89(10).

Wei, Y., et al. (2025). Effects of dietary supplements on bone turnover markers in women after menopause. PeerJ.

Maki, K.C., et al. (2021). Omega-3 polyunsaturated fatty acids and cardiovascular disease. Journal of the American College of Cardiology. 77(22).

Dibaba, D.T., et al. (2017). Associations between magnesium intake and serum lipids. American Journal of Clinical Nutrition. 106(1).

Dennerstein, L., et al. (2014). Menopausal hot flushes. American Journal of Medicine. 127(12).

This represents one stack in the Precision Longevity supplement collection. For a comprehensive consultation on which stacks are right for you, visit precisionlongevity.life or schedule a consultation.