Cellular energy, mitophagy, and healthy aging support in one foundational daily protocol.
Here's a number that stops most people: NAD+ levels drop roughly 50% between ages 40 and 60. NAD+ is the molecule your cells need to produce energy, repair DNA, and activate the longevity pathways that keep you functioning at your best.
For anyone looking to optimise the foundational mechanisms of cellular aging. Ideal if you're experiencing fatigue, want to support longevity pathways, or are seeking a comprehensive micronutrient base.
The Foundation of Cellular Wellness
Who is this for?
For anyone looking to optimise the foundational mechanisms of cellular ageing. Ideal if you’re experiencing fatigue, want to support longevity pathways, or are seeking a comprehensive micronutrient base.
Here’s a number that stops most people: NAD+ levels drop roughly 50% between the ages of 40 and 60. NAD+ is the molecule your cells need to produce energy, repair DNA, and activate the longevity pathways (sirtuins) that keep you functioning at your best. When it drops, everything downstream starts to slow. Energy production slows. Cellular cleanup slows. Your body’s ability to clear out old, damaged cells that have stopped working but refuse to leave slows. Think of it like the maintenance crew in a large building. When the crew is fully staffed, everything runs smoothly. Lights get fixed. Trash gets taken out. Broken equipment gets replaced. But when you cut the crew in half? Things pile up. That’s what happens at the cellular level as we age. Precision Longevity Core is designed to address the foundational mechanisms of cellular ageing. NAD+ replenishment. Mitochondrial quality control (mitophagy). Senolytic support. And the broad-spectrum micronutrient base your body needs to run over 300 enzymatic reactions every day. This is the stack we’d suggest everyone starts with, because these are the pathways that everything else depends on.
Daily dose: 8 caps/day | Timing: AM + PM
Ingredient Dose Timing Role in This Formula NMN 600mg (AOR NMN-600) 1 cap AM NAD+ precursor. Supports cellular energy, DNA repair, and sirtuin activation. Urolithin A (AOR Urolithin A+) 1 cap AM Mitophagy activator. Clears damaged mitochondria and supports muscle endurance. Multi Basics 3 (AOR) 2 caps AM + PM Activated B vitamins. Foundational micronutrient base. Omega-3 EPA/DHA (DFH OmegaAvail Hi-Po) 2 caps AM Anti-inflammatory support for cardiovascular health, brain function, and cell membrane integrity. Quercetin 500mg (AOR) 1 cap PM Senolytic support, DNA repair, antioxidant function, blood pressure support. D3 2500IU + K2 MK-7 (AOR) 1 cap PM Bone density, vascular calcification prevention, immune modulation. Magnesium Bisglycinate 200mg (CanPrev) 1 cap PM Supports over 300 enzymatic reactions. Sleep, cardiovascular health, glucose regulation.
Companion Powders: Precision Creatine (5g/day) + Precision Fibre (5-10g/day)
Why each ingredient is here.
RCT confirms NAD+ elevation and significant improvement in physical performance metrics at 600mg/day. NAD+ is the coenzyme at the centre of cellular energy production. When levels are restored, the downstream effects touch everything from mitochondrial function to DNA repair capacity. Citation: Yoshino, M., et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 372(6547).
Published in JAMA Network Open: Urolithin A significantly improved muscle endurance and mitochondrial gene expression vs placebo. Here’s the key. Urolithin A activates mitophagy, which is your cell’s quality control system for mitochondria. Think of it as the foreman who identifies which machines on the factory floor need to be retired and replaced with new ones. Our ability to produce urolithin A from dietary sources (like pomegranate) declines with age and microbiome changes, which is exactly why supplementation becomes relevant. Citation: Andreux, P.A., et al. (2019). The mitophagy activator urolithin A is safe and induces a signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 1(6).
Senolytic activity confirmed across multiple studies. A senolytic is something that helps clear ‘zombie cells’. Cells that have stopped dividing but refuse to die, and instead sit around releasing inflammatory signals that damage their neighbours. Meta-analysis also confirms significant blood pressure support and reduction in inflammatory markers TNF-alpha and IL-6. Citation: Popiolek-Kalisz, J., et al. (2022). The effects of quercetin supplementation on blood pressure. Current Problems in Cardiology. 47(2).
Meta-analysis of 171 clinical trials: significant reductions in triglycerides, systolic and diastolic blood pressure, heart rate, and CRP. This isn’t a subtle effect. It’s one of the most consistently supported supplements in the entire research literature. An omega-3 index of 8% or above is associated with 15-25% lower coronary heart risk in prospective studies. Citation: Maki, K.C., et al. (2021). Omega-3 polyunsaturated fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. Journal of the American College of Cardiology. 77(22).
Network meta-analysis ranks D3+K2 as optimal for bone formation. But here’s the part most people miss: K2 (MK-7) activates Matrix Gla Protein, which is the mechanism that directs calcium to your bones instead of your arteries. D3 without K2 is an incomplete conversation. Citation: Wei, Y., et al. (2025). Effects of dietary supplements on bone turnover markers in women after menopause. PeerJ.
Meta-analysis of 38 RCTs: significant reductions in systolic blood pressure, diastolic blood pressure, fasting glucose, lipids, and CRP. Up to 70% of adults are magnesium deficient. This one mineral is involved in over 300 enzymatic reactions. Bisglycinate is the form your body absorbs best without the digestive upset of cheaper alternatives. Citation: Dibaba, D.T., et al. (2017). Associations between magnesium intake, all-cause serum magnesium, and serum lipids in the Bogalusa Heart Study. American Journal of Clinical Nutrition. 106(1).
Vitamin D3 in Multiple Stacks: D3 is a fat-soluble vitamin that accumulates over time. If you are taking more than one Precision stack that contains D3 (2,500 IU), please confirm with your healthcare provider that your combined daily total does not exceed 5,000 IU.
Omega-3 and Blood-Thinning Medications: If you are taking blood-thinning medications such as warfarin, aspirin, or clopidogrel, please share this with your prescribing physician before adding omega-3 supplementation, as there may be additive effects on bleeding time.
NMN Tolerability: Generally very well tolerated. If you have a personal or family history of hormone-sensitive conditions, share this with your healthcare provider as NMN supports hormonal enzymatic pathways.
Quercetin Drug Interactions: May interact with cyclosporin, certain antibiotics (quinolones), and blood-thinning medications. If you are on any prescription medication, please review with your healthcare provider.
Health Canada/FDA: These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Educational Purpose: The evidence summaries provided are for educational purposes and represent published research findings. Individual results may vary. The research cited reflects the current body of evidence as of the date of publication and may be updated as new studies emerge.
Medical Consultation: This product is a wellness supplement, not a prescription medication. It is not a substitute for medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, taking medication, or have a pre-existing health condition.
Drug Interactions: Some ingredients in this formula may interact with prescription medications. Please review the Important Considerations section and share this information with your prescribing physician.
Dev Note (CPSO Compliance): All content on this page is educational and wellness-focused. No diagnostic or prescriptive claims are made. Content complies with CPSO advertising guidelines.
NAD+ and mitochondrial pathways typically show measurable changes within 3-6 weeks, though many people report increased energy and mental clarity within 2-3 weeks. Senolytic effects (zombie cell clearance) and systemic anti-inflammatory benefits typically take 6-8 weeks to fully manifest. Bone-related benefits (from D3+K2) follow a slower timeline of 8-12 weeks.
Most ingredients in this stack are well-tolerated alongside standard medications. However, Quercetin may interact with blood-thinners and certain antibiotics. Omega-3 may have additive effects with anticoagulants. NMN and other ingredients generally have minimal interaction risks. Always share this list with your prescribing physician.
This stack contains 2 caps of OmegaAvail Hi-Po (approximately 1000mg combined EPA+DHA per serving). If you’re already supplementing omega-3, do not double up without consulting your healthcare provider. Your combined daily intake should remain within evidence-based dosing (1000-2000mg combined EPA+DHA daily).
Yes. Every ingredient in this formula has decades of RCT evidence supporting safe long-term use. NMN, Quercetin, Omega-3, D3+K2, and Magnesium Bisglycinate are all supported by multi-year safety data. This is designed as a foundational daily supplement to support the mechanisms of healthy ageing over years and decades.
Yoshino, M., et al. (2021). Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 372(6547).
Andreux, P.A., et al. (2019). The mitophagy activator urolithin A is safe and induces a signature of improved mitochondrial and cellular health in humans. Nature Metabolism. 1(6).
Popiolek-Kalisz, J., et al. (2022). The effects of quercetin supplementation on blood pressure. Current Problems in Cardiology. 47(2).
Maki, K.C., et al. (2021). Omega-3 polyunsaturated fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. Journal of the American College of Cardiology. 77(22).
Wei, Y., et al. (2025). Effects of dietary supplements on bone turnover markers in women after menopause. PeerJ.
Dibaba, D.T., et al. (2017). Associations between magnesium intake, all-cause serum magnesium, and serum lipids in the Bogalusa Heart Study. American Journal of Clinical Nutrition. 106(1).
This represents one stack in the Precision Longevity supplement collection. For a comprehensive consultation on which stacks are right for you, visit precisionlongevity.life or schedule a consultation.
| Ingredient / Detail | Dose / Value | Timing | Why It Matters |
|---|---|---|---|
NMN 600mg (AOR NMN-600) NAD+ precursor Timing: AM Supports cellular energy, DNA repair, and sirtuin activation. | 1 cap | AM | Supports cellular energy, DNA repair, and sirtuin activation. |
Urolithin A (AOR Urolithin A+) Mitophagy activator Timing: AM Clears damaged mitochondria and supports muscle endurance. | 1 cap | AM | Clears damaged mitochondria and supports muscle endurance. |
Multi Basics 3 (AOR) Activated multinutrient base Timing: AM + PM Provides activated B vitamins and foundational micronutrient coverage. | 2 caps | AM + PM | Provides activated B vitamins and foundational micronutrient coverage. |
Omega-3 EPA/DHA (DFH OmegaAvail Hi-Po) High-potency fish oil Timing: AM Supports cardiovascular health, brain function, and cell membrane integrity. | 2 caps | AM | Supports cardiovascular health, brain function, and cell membrane integrity. |
Quercetin 500mg (AOR) Polyphenol senolytic support Timing: PM Supports senolytic activity, antioxidant defence, and blood pressure balance. | 1 cap | PM | Supports senolytic activity, antioxidant defence, and blood pressure balance. |
D3 1000IU + K2 (CanPrev) Vitamin D + K complex Timing: PM Supports bone density, vascular calcium routing, and immune modulation. | 2 caps | PM | Supports bone density, vascular calcium routing, and immune modulation. |
Magnesium Bisglycinate 200mg (CanPrev) Chelated magnesium Timing: PM Supports sleep, cardiovascular health, glucose regulation, and over 300 enzymatic reactions. | 1 cap | PM | Supports sleep, cardiovascular health, glucose regulation, and over 300 enzymatic reactions. |
When NAD+ falls, everything downstream starts to slow. Energy production slows. Cellular cleanup slows. Your body's ability to clear out old, damaged cells slows too. Think of it like a maintenance crew in a large building. When the crew is fully staffed, everything runs smoothly. Cut that crew in half, and things start to pile up.
Precision Longevity Core is designed around the foundational mechanisms of cellular aging: NAD+ replenishment, mitochondrial quality control, senolytic support, and the broad-spectrum micronutrient base your body needs to run hundreds of enzymatic reactions every day. This is the stack we'd suggest most people start with, because these are the pathways everything else depends on.
Educational summary. Not a substitute for personalised medical advice.
Human trial data confirms meaningful NAD+ elevation and improved physical performance metrics at 600mg daily. NAD+ sits at the center of cellular energy production, DNA repair, and metabolic signalling, so restoring it has system-wide implications.
Published human data shows Urolithin A improves muscle endurance and mitochondrial gene expression versus placebo. It works by activating mitophagy, the quality-control pathway that helps your cells retire damaged mitochondria and replace them with healthier ones.
Quercetin has senolytic relevance across multiple studies and meta-analytic support for modest blood pressure improvement plus reductions in inflammatory markers such as TNF-alpha and IL-6. It helps support clearance of dysfunctional, pro-inflammatory cells.
A large evidence base shows omega-3s reduce triglycerides, blood pressure, heart rate, and inflammatory tone. It remains one of the most consistently supported supplements in the literature for cardiovascular and membrane health.
D3 and K2 work as a pair. D3 supports calcium absorption and immune signalling, while K2 helps direct that calcium into bone rather than soft tissue. This is especially relevant when longevity support also means preserving bone and vascular health over time.
Magnesium participates in hundreds of enzymatic reactions tied to glucose regulation, cardiovascular tone, sleep quality, and stress resilience. The bisglycinate form is well tolerated and avoids the GI irritation associated with lower-quality forms.
If you are taking blood-thinning medications such as warfarin, aspirin, or clopidogrel, review the omega-3 portion of this stack with your prescribing physician before starting.
Quercetin may interact with certain antibiotics, cyclosporin, and blood-thinning medications. If you use prescription medications, review this stack with your healthcare provider first.
NMN is generally well tolerated, but if you have a personal or family history of hormone-sensitive conditions, share this formula with your healthcare provider before starting.
Vitamin D3 is fat-soluble and accumulates over time. If you are using more than one Precision stack that contains D3, confirm with your healthcare provider that your combined daily total remains appropriate for you.
Important. These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. The evidence summaries provided are for educational purposes only and represent published research findings - they are not claims about this specific product's ability to treat any condition. If you are pregnant, nursing, taking medication, or have a health condition, please consult your healthcare provider before use.