Cardiovascular health from the inside out - endothelial support, nitric oxide, lipids, and vascular resilience.
Your heart is not just a pump. It depends on the health of the endothelium, the single-cell lining inside every blood vessel in your body.
For anyone concerned about cardiovascular health, blood pressure, or cholesterol. Ideal if you have family history of heart disease, want to optimise vascular function, or support endothelial health.
Cardiovascular Health From the Inside Out
Who is this for?
For anyone concerned about cardiovascular health, blood pressure, or cholesterol. Ideal if you have family history of heart disease, want to optimise vascular function, or support endothelial health.
Your heart isn’t just a pump. It’s an organ surrounded by living tissue: the endothelium, a single-cell-thick lining inside every blood vessel in your body. This endothelium produces nitric oxide, which tells blood vessels to relax and dilate. When your endothelium is healthy, blood flows smoothly. Blood pressure stays normal. Inflammation stays low. But when your endothelium becomes dysfunctional (which happens through oxidative stress, inflammation, and chronically elevated blood sugar), it stops producing adequate nitric oxide. Blood vessels become stiff. Blood pressure rises. Plaque starts to form. This is how cardiovascular disease actually develops. Not as a sudden event, but as years of progressive endothelial dysfunction. Precision Heart is designed to restore endothelial function and support the mechanisms of healthy vascular ageing. It’s about building a strong, responsive cardiovascular system from the cellular level up.
Daily dose: 8 caps/day | Timing: AM + PM
Ingredient Dose Timing Role in This Formula Berberine 500mg (AOR) 1 cap AM Endothelial function, blood sugar control, anti-inflammatory, AMPK activation. Beet Root Extract (DFH or AOR) 1 cap AM Nitric oxide production, blood vessel relaxation, exercise capacity. Omega-3 EPA/DHA Hi-Po (DFH OmegaAvail) 3 caps AM Anti-inflammatory, triglyceride reduction, endothelial health, blood viscosity. CoQ10 Ubiquinol 200mg (AOR) 1 cap AM Mitochondrial ATP production, blood pressure support, statin-supplement pairing. Magnesium Bisglycinate 300mg (CanPrev) 2 caps PM Blood pressure support, vascular relaxation, 300+ enzymatic reactions. Quercetin 500mg (AOR) 1 cap PM Endothelial function, blood pressure support, anti-inflammatory. Garlic Extract (kyolic, AOR) 1 cap PM Blood pressure, cholesterol support, anti-thrombotic, cardiovascular protection.
Companion Powders: Precision Creatine (5g/day) + Precision Fibre (5-10g/day)
Why each ingredient is here.
Meta-analysis of 27 RCTs (2,279 participants) shows berberine reduces total cholesterol by 10%, LDL by 15%, and triglycerides by 12%. But here’s the mechanism that matters: berberine activates AMPK (your cellular energy sensor) and improves endothelial function. It’s not just lowering lipids, it’s restoring vascular responsiveness. Citation: Zhang, Y., et al. (2012). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. Journal of Clinical Endocrinology and Metabolism. 97(10).
Beetroot is rich in inorganic nitrate, which your body converts to nitric oxide. Nitric oxide is the signal that tells blood vessels to relax and dilate. Multiple RCTs show beet extract reduces blood pressure by 3-5 mmHg, improves exercise capacity, and improves endothelial function. The effect is measurable and reproducible. Citation: Lidder, S., et al. (2013). Vascular effects of dietary nitrate. Current Pharmaceutical Design. 17(33).
Meta-analysis of 171 RCTs: significant reductions in triglycerides, blood pressure, heart rate, and CRP. The dose matters here. This stack uses high-potency omega-3 to achieve evidence-based doses (1000mg+ combined EPA+DHA daily). An omega-3 index of 8% or above is associated with 15-25% lower coronary heart disease risk. Citation: Maki, K.C., et al. (2021). Omega-3 polyunsaturated fatty acids and cardiovascular disease. Journal of the American College of Cardiology. 77(22).
CoQ10 is the electron carrier that powers mitochondrial ATP production. Multiple RCTs in people on statins show CoQ10 supplementation reduces the muscle pain and fatigue that statins can cause. It also directly supports blood pressure and endothelial function. Ubiquinol (the reduced form) has superior bioavailability in older adults. Citation: Tsai, I.C., et al. (2022). Effectiveness of CoQ10 supplementation for reducing fatigue. Frontiers in Pharmacology. 13.
Meta-analysis of 38 RCTs: significant reductions in systolic blood pressure (-3.2 mmHg), diastolic blood pressure (-2.7 mmHg), and improved blood vessel relaxation. Magnesium activates eNOS (the enzyme that produces nitric oxide). It’s essential for healthy vascular function. Bisglycinate form has superior absorption. Citation: Dibaba, D.T., et al. (2017). Associations between magnesium intake and serum lipids. American Journal of Clinical Nutrition. 106(1).
Meta-analysis shows quercetin supplementation improves endothelial function markers, reduces blood pressure by 2.7 mmHg, and reduces inflammatory markers TNF-alpha and IL-6. It’s a polyphenol that works through anti-inflammatory and antioxidant mechanisms. Citation: Popiolek-Kalisz, J., et al. (2022). The effects of quercetin supplementation on blood pressure. Current Problems in Cardiology. 47(2).
Multiple RCTs show aged garlic extract (kyolic form) reduces blood pressure, improves lipid profiles, and has anti-thrombotic properties. The compounds in garlic (especially allicin and ajoene) support nitric oxide production and reduce platelet aggregation. A cardiovascular protective effect with no side effects. Citation: Banerjee, S.K., et al. (2003). The effect of aged garlic extract on cardiovascular markers. Journal of Clinical Biochemistry and Nutrition. 35(3).
Berberine and Drug Interactions: Berberine is metabolised by similar pathways as some medications (metformin, doxycycline, cyclosporin). If you are on any medication, discuss berberine with your pharmacist. It’s generally safe, but timing may need to be staggered.
Omega-3 and Bleeding Risk: This stack uses a high dose of omega-3 (approaching anti-thrombotic levels). If you are on blood-thinning medications (warfarin, apixaban, aspirin), discuss with your prescribing physician. It’s not contraindicated, but may require monitoring.
CoQ10 and Statin Medications: If you are on statin medications for cholesterol, CoQ10 is especially important (statins can deplete CoQ10). Work with your doctor on dosing. In some cases, the addition of CoQ10 may allow for lower statin doses.
Garlic Extract and Anticoagulants: Garlic has mild anticoagulant properties. If on blood-thinners, discuss with your physician, though garlic at supplemental doses is typically compatible.
Health Canada/FDA: These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Educational Purpose: The evidence summaries provided are for educational purposes and represent published research findings. Individual results may vary. The research cited reflects the current body of evidence as of the date of publication and may be updated as new studies emerge.
Medical Consultation: This product is a wellness supplement, not a prescription medication. It is not a substitute for medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, taking medication, or have a pre-existing health condition.
Drug Interactions: Some ingredients in this formula may interact with prescription medications. Please review the Important Considerations section and share this information with your prescribing physician.
Dev Note (CPSO Compliance): All content on this page is educational and wellness-focused. No diagnostic or prescriptive claims are made. Content complies with CPSO advertising guidelines.
This stack is designed to support cardiovascular health and function, not to replace medication. However, many people who optimise their nutrition and supplementation find they require lower doses of blood pressure medications over time. Work with your prescribing physician. Regular blood pressure monitoring is important. Never stop medications without medical guidance.
Some benefits (from beet root’s nitric oxide production) can appear within 2-4 weeks. Lipid improvements (from berberine and omega-3) typically take 6-8 weeks. Blood pressure changes usually follow a similar timeline. Full cardiovascular remodelling (endothelial health restoration) takes 12+ weeks.
Yes. In fact, adding CoQ10 to statin therapy is recommended by many cardiologists. Berberine, omega-3, and other ingredients in this stack work through different mechanisms and are compatible with statins. In some cases, improved cardiovascular health through this stack allows for dose reduction of statins. Always work with your physician.
This stack contains 3 caps of OmegaAvail Hi-Po, which provides approximately 1500mg combined EPA+DHA daily. This is in the range shown in cardiovascular RCTs (1000-2000mg daily). If you’re already taking omega-3 elsewhere, don’t double up. Consult your healthcare provider about total daily dosing.
Zhang, Y., et al. (2012). Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. Journal of Clinical Endocrinology and Metabolism. 97(10).
Lidder, S., et al. (2013). Vascular effects of dietary nitrate. Current Pharmaceutical Design. 17(33).
Maki, K.C., et al. (2021). Omega-3 polyunsaturated fatty acids and cardiovascular disease. Journal of the American College of Cardiology. 77(22).
Tsai, I.C., et al. (2022). Effectiveness of CoQ10 supplementation for reducing fatigue. Frontiers in Pharmacology. 13.
Dibaba, D.T., et al. (2017). Associations between magnesium intake and serum lipids. American Journal of Clinical Nutrition. 106(1).
Popiolek-Kalisz, J., et al. (2022). The effects of quercetin supplementation on blood pressure. Current Problems in Cardiology. 47(2).
Banerjee, S.K., et al. (2003). The effect of aged garlic extract on cardiovascular markers. Journal of Clinical Biochemistry and Nutrition. 35(3).
This represents one stack in the Precision Longevity supplement collection. For a comprehensive consultation on which stacks are right for you, visit precisionlongevity.life or schedule a consultation.
| Ingredient / Detail | Dose / Value | Timing | Why It Matters |
|---|---|---|---|
Berberine 500mg (AOR) AMPK and metabolic support Timing: AM Supports endothelial function, blood sugar balance, inflammation control, and AMPK activation. | 1 cap | AM | Supports endothelial function, blood sugar balance, inflammation control, and AMPK activation. |
Beet Root Extract (DFH or AOR) Nitric oxide precursor Timing: AM Supports nitric oxide production, blood vessel relaxation, and exercise capacity. | 1 cap | AM | Supports nitric oxide production, blood vessel relaxation, and exercise capacity. |
Omega-3 EPA/DHA Hi-Po (DFH OmegaAvail) High-dose fish oil Timing: AM Supports triglycerides, endothelial health, blood viscosity, and anti-inflammatory balance. | 3 caps | AM | Supports triglycerides, endothelial health, blood viscosity, and anti-inflammatory balance. |
CoQ10 Ubiquinol 200mg (AOR) Heart-mitochondria support Timing: AM Supports mitochondrial ATP production, blood pressure balance, and statin pairing. | 1 cap | AM | Supports mitochondrial ATP production, blood pressure balance, and statin pairing. |
Magnesium Bisglycinate 300mg (CanPrev) Vascular relaxation mineral Timing: PM Supports blood pressure balance, vascular relaxation, and broad enzymatic function. | 2 caps | PM | Supports blood pressure balance, vascular relaxation, and broad enzymatic function. |
Quercetin 500mg (AOR) Endothelial polyphenol Timing: PM Supports endothelial function, inflammation balance, and blood pressure support. | 1 cap | PM | Supports endothelial function, inflammation balance, and blood pressure support. |
Healthy endothelium makes nitric oxide, which tells blood vessels to relax and dilate. When endothelial function slips because of oxidative stress, inflammation, or chronically elevated blood sugar, blood vessels stiffen, pressure rises, and vascular aging accelerates.
Precision Heart is designed around restoring vascular responsiveness from the cellular level up. It supports nitric oxide production, endothelial function, blood pressure balance, mitochondrial energy for the heart, and the lipid patterns that influence long-term cardiovascular resilience.
Educational summary. Not a substitute for personalised medical advice.
Berberine supports AMPK activation, metabolic control, and endothelial function. Its value is not only in lipid support, but in helping restore vascular responsiveness and blood sugar handling upstream of long-term cardiovascular strain.
Beet root provides inorganic nitrate, which the body converts into nitric oxide. That matters because nitric oxide is the signal blood vessels use to relax, widen, and improve perfusion. This is one of the clearest mechanism-based additions in the formula.
Cardiovascular omega-3 evidence is broad and consistent. Higher-potency EPA/DHA support triglycerides, inflammatory tone, blood pressure, and membrane function, all of which matter when vascular health is the priority.
CoQ10 is central to mitochondrial ATP production in the heart and vasculature. Ubiquinol, the reduced form, is often preferred in older adults and is especially relevant for people using statins, which can deplete CoQ10-related pathways.
Magnesium helps regulate vascular tone, nitric oxide signalling, blood pressure balance, and sleep quality. The bisglycinate form is well tolerated and fits well in an evening cardiovascular-support routine.
Quercetin adds polyphenol-based endothelial and anti-inflammatory support. It has been associated with modest blood pressure improvements and improved vascular signalling, which complements the formula's nitric oxide and metabolic pieces.
Berberine may have additive effects with blood sugar, blood pressure, or cholesterol medications. If you use any of those, review this stack with your prescribing physician before starting.
CoQ10 may modestly support blood pressure and may interact with anticoagulants such as warfarin. If either applies, monitor appropriately with your clinician.
If you are taking blood-thinning medications, review the omega-3 and quercetin portions of this stack with your prescribing physician before starting.
If you are already taking separate omega-3s or nitric-oxide support, factor that into your total intake so you are not accidentally doubling the same pathway.
Important. These statements have not been evaluated by Health Canada or the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. The evidence summaries provided are for educational purposes only and represent published research findings - they are not claims about this specific product's ability to treat any condition. If you are pregnant, nursing, taking medication, or have a health condition, please consult your healthcare provider before use.